No. 4: Andrew Ryan in BioShock

The first BioShock was full of twists and turns, but none stood out more than finding out you were merely a pawn in a larger scheme. Brainwashed and conditioned to do whatever the person with the control phrase asked you to, the final confrontation with Andrew Ryan takes an unexpected turn. Normally, villains try to fight for their lives, but in this case, Ryan orders you to take his, while getting a final dig in at the same time. The whole situation is incredibly disturbing, and it’s made even more so by the sound design. You’ll never look at a putter the same way again.