While BioWare has already committed to Mass Effect 4 taking place in an entirely different part of that universe, it seems the developer might not be done with some familiar faces from the first three games.
The Mass Effect trilogy starring Commander Shepard and his crew may have ended with Mass Effect 3, but adventures in the Mass Effect universe surely haven't. A PAX East panel that presented a retrospective on BioWare's sci-fi role-playing game had a few details on the next game in the series.